Newer Lung Cancer Drug Alone Beats Older Combination Therapy in Real-World Study
A large real-world study in China found that third-generation EGFR inhibitor monotherapy extended progression-free survival in advanced EGFR-mutant lung cancer ...
Tag: Real-world evidence
Integrase Inhibitors Suppress HIV Faster but Bring Metabolic Trade-offs in Real-World Chinese Cohort
A province-wide cohort study of 7,474 treatment-naïve adults in Shandong, China finds INSTI-based initial HIV therapy outperforms NNRTI-based regimens on ...
Tildrakizumab Shows Sustained Real-World Benefit in Japanese Psoriasis Patients Over 52 Weeks
A 52-week Japanese observational study found that tildrakizumab sustained meaningful disease control in real-world psoriasis patients, with 60 percent achieving ...
Early CFTR Modulator Therapy Shows Real-World Benefits in Preschool Children with Cystic Fibrosis
A multicenter Italian study and an accompanying commentary provide real-world evidence that early lumacaftor/ivacaftor therapy improves CFTR function biomarkers and ...
Intravenous Esketamine Acts Faster, but Subcutaneous Route Matches Final Outcomes in Treatment-Resistant Depression
A multicenter Brazilian study finds intravenous esketamine produced faster antidepressant response in treatment-resistant depression, while a longer subcutaneous protocol achieved ...
Liraglutide Doses Below 3.0 mg Show Real-World Benefit, but Cost Blocks Half of Patients
A Taiwanese post-marketing surveillance study finds that nearly half of patients who failed to reach the approved 3.0 mg liraglutide ...
Mepolizumab Edges Out Dupilumab in Head-to-Head Real-World Asthma Biologic Showdown Among Older Medicare Patients
A large real-world study of Medicare beneficiaries found mepolizumab matched dupilumab for preventing asthma hospitalizations and significantly reduced exacerbation rates, ...
Hungary’s Decade of Data Reveals the Harsh Reality of Extensive-Stage Small Cell Lung Cancer
A nationwide analysis of 8,104 Hungarian patients treated from 2013 to 2022 shows median survival of just 9.3 months with ...
Diabetes Does Not Raise the Risk of Revision ACL Reconstruction, Large Real-World Study Finds
A study of nearly 74,000 patients across 53 healthcare organisations found that diabetes mellitus was not associated with an increased ...
Dual-Targeted Therapy Brings Remission to Half of Patients with Hardest-to-Treat Inflammatory Bowel Disease
A real-world study from Abu Dhabi found that pairing two advanced therapies with different mechanisms achieved combined clinical and biochemical ...
Real-World Data Show Lecanemab Is Mostly Safe but Flag a Stroke Signal
A combined real-world cohort and FAERS analysis finds lecanemab generally safe in Alzheimer's patients but flags a strong, unlabeled signal ...
Proteasome Inhibitors Fail to Show Measurable Bone and Quality-of-Life Benefits in Myeloma Patients
A prospective real-world cohort study finds that proteasome inhibitor-based therapy is not associated with measurable differences in quality of life, ...
Skin Disease, Silent Metabolism: Large Database Study Links Hidradenitis Suppurativa to Type 2 Diabetes
A large real-world analysis of electronic health records using the TriNetX network indicates that patients with hidradenitis suppurativa face an ...
Antibody-Drug Conjugate Shows Striking First-Line Results in HER2-Driven Lung Cancer
A multicenter real-world study found that first-line trastuzumab deruxtecan doubled progression-free survival compared with chemotherapy in HER2-altered advanced NSCLC, while ...
Who Counts? Single-Center Audit Probes Whether a National Psoriasis Registry Truly Reflects Real Patients
Researchers compared the national FORWARD psoriasis registry against a single academic institution's electronic medical records to test whether its voluntary, ...
Stem Cell Models to Reveal Why Parkinson’s Disease Hits Women Differently
Critical Path Institute and the University of Arizona have launched a two-year collaboration using human stem cell-derived neurons and new ...
Why the Best Drugs Fail: The Widening Medication Adherence Gap
A new PLOS Medicine Perspective argues that the widening gap between drug efficacy in trials and real-world effectiveness is driven ...
Rescue Stents May Turn Failed Stroke Procedures Into Better Outcomes, German Registry Suggests
A propensity score-matched analysis of the German Stroke Registry finds that rescue intracranial stenting after failed thrombectomy is associated with ...
Ravulizumab in Pregnancy Shows No New Safety Signals in Global Analysis
A global pharmacovigilance analysis of 354 pregnancies found no unexpected safety signals with the complement inhibitor ravulizumab, with outcomes consistent ...
Real-World Data Show Carfilzomib Regimens Deliver Strong Results in Multiple Myeloma
The final results of the German CARO study show that carfilzomib-based regimens achieve high adherence, trial-consistent effectiveness, and stable quality ...
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