How Low Oxygen Helps Neuroblastoma Turn Killer T Cells Off
New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...
Tag: Neuroblastoma
Cancer Protein LGALS3BP Reshapes the Cargo of Neuroblastoma Extracellular Vesicles
New research links the secreted glycoprotein LGALS3BP to selective enrichment of microRNAs and the RNA-binding protein SRSF1 in neuroblastoma extracellular ...
Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Cancer’s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors
New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better ...
Nuclear Medicine Advances Span Prostate Cancer, Stroke, and Diabetes Imaging
New ahead-of-print studies in The Journal of Nuclear Medicine describe advances in prostate cancer theranostics, enzyme-enhanced tumor imaging, novel PET ...
Gene Signature Exposes Hidden Neuroblastoma Cells That Drive Poor Outcomes
St. Jude scientists and collaborators built a comprehensive single-cell dataset and patient-derived models to identify a malignant mesenchymal cell population ...
MRI Technique Reads Tumor Chemistry to Sort Risky Childhood Cancers Before Surgery
A Chinese research team shows that amide proton transfer MRI combined with machine learning can noninvasively distinguish high-risk from non-high-risk ...
Blocking a Single Protein Makes Childhood Cancer Cells Easier for Immunotherapy to Find
Penn State researchers found that blocking the protein VPS34 raises levels of the GD2 molecule on neuroblastoma cells, making them ...
Tracer Debate: Fluorinated MIBG Alternative Sparks Scientific Exchange in Neuroblastoma Imaging
A scientific exchange in Pediatric Radiology over the merits of fluorinated MIBG PET imaging highlights the evidence still needed before ...
Rare Neurological Diseases in Children Are Rising Worldwide, First Global Analysis Finds
The first global assessment of rare neurological diseases in children finds rising prevalence and disability from 1990 to 2021, declining ...
CNTNAP2 Identified as Tumor Suppressor in Neuroblastoma
In a groundbreaking study published in the Journal of Translational Medicine, researchers Liu, Y., Zhao, J., and Wang, K., among ...
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