How Stressed Blood Flow and Metabolism Drive Ageing Arteries
A new review proposes that disturbed blood flow and metabolic stress converge to drive endothelial cell senescence, amplifying cardiometabolic vascular ...
Tag: Chronic Kidney Disease
Scientists Pinpoint a Blood Protein That Helps Drive Kidney Disease in Diabetes
A large mendelian randomization study identifies the circulating protein INHBC as a mediator linking Type 2 diabetes to chronic kidney ...
Diseased Kidneys Age Faster at the Cellular Level, Single-Cell Epigenome Atlas Reveals
A cross-species single-cell epigenome atlas shows that kidney disease accelerates epigenetic aging most dramatically in tubular epithelial cells, which lose ...
Pregnancy Complications May Set the Stage for Heart, Kidney and Metabolic Disease Decades Later
A 44-year UK Biobank study of over 165,000 women finds that adverse pregnancy outcomes more than triple the risk of ...
How Broken Mitochondria Drive the Scarring That Slowly Kills the Kidneys
A sweeping new review argues that damaged mitochondria in kidney tubule cells act as both trigger and amplifier of the ...
Pregnancy complications may signal later heart and kidney disease risk, study of 1.4 million women finds
A UK study of 1.4 million women links pregnancy complications such as gestational diabetes, pre-eclampsia, and postnatal depression to elevated ...
RNA-Binding Protein PTBP3 Drives Kidney Scarring in Diabetes, Study Finds
Researchers at Harbin Medical University report that the RNA-binding protein PTBP3 stabilizes SMAD3 mRNA and drives podocyte epithelial-to-mesenchymal transition, and ...
Eye Damage in Diabetes May Signal Hidden Kidney and Leg Artery Disease
A large Chinese cross-sectional study of 3,000 patients with type 2 diabetes finds that diabetic retinopathy is strongly associated with ...
Obesity, Skin Barriers and Swelling Drive Cellulitis Risk, Large Study Finds
A large retrospective case-control study from the Medical University of Vienna identifies skin barrier breaches, oedema, obesity and other factors ...
Rare Genetic Syndrome Unmasked by Sudden Kidney Failure in Young Woman
A case report from Lahore describes a 27-year-old woman whose sudden kidney failure revealed both advanced undiagnosed chronic kidney disease ...
Kidney Damage, Not Blood Sugar Alone, Drives Hospital Stays in Oldest Diabetes Patients
A Swedish population-based study of adults aged 75 and older with type 2 diabetes finds that advanced chronic kidney disease ...
Forcing Kidney Cells to Divide Reveals a Hard Limit on Glomerular Growth
A transgenic mouse study shows that SV40T-induced podocyte proliferation, even during embryonic development, fails to enlarge glomeruli because surplus cells ...
Mint Compound L-Carvone Shows Promise Against Uremia-Driven Blood Vessel Damage in Kidney Disease
Brazilian researchers report that the spearmint-derived monoterpene L-carvone reduced inflammatory biomarkers, monocyte recruitment, and structural damage in human endothelial cells ...
Popular Gene Pathway Scoring Tools Can Silently Erase Disease Signals, Benchmark Warns
A new benchmark of pathway activity scoring methods in single-cell RNA-seq reveals that top-rank-window tools like AUCell and UCell can ...
Insights on Hypertensive Nephropathy in Xinjiang Patients
In recent years, the nexus between hypertension and nephropathy has garnered increased attention in the medical community, particularly in regions ...
Hepatokine Fibrinogen-Like Protein 1 Fuels Kidney Fibrosis
In a groundbreaking discovery set to redefine our understanding of organ interplay, researchers have identified a pivotal molecular mediator that ...
Understanding CKD and Anticoagulation Risks in Seniors
The rising prevalence of chronic kidney disease (CKD) alongside atrial fibrillation (AF) in older adults has emerged as a significant ...
Challenges and Outcomes in High-Risk Proteinuria CKD Patients
Chronic Kidney Disease (CKD) represents a major health challenge globally, affecting millions of individuals and substantially impacting societies and healthcare ...
