Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, ...
Tag: biomarkers
Blood Protein Test Predicts Seven Years of Nerve Damage in Rare Genetic Disease
A seven-year Dutch study shows that a single baseline blood measurement of neurofilament light chain predicts the pace of spinal ...
New Biomarkers and AI Aim to Cut Unnecessary Prostate Biopsies Before the Needle
A new review in Medical Oncology details how liquid biomarkers, advanced imaging, and artificial intelligence are transforming pre-biopsy discrimination of ...
Clinical Risk Scores Cannot Stand In for Neurofilament Biomarkers in ALS Trials, Study Finds
A reanalysis of the MIROCALS trial shows that the TRICALS clinical risk score adds useful prognostic information in ALS but ...
Follicular Fluid Proteins Reveal Metabolic and Immune Clues in Ovarian Syndrome
Using 4D label-free proteomics, researchers identified 33 differentially expressed proteins in follicular fluid from patients with polyendocrine metabolic ovarian syndrome, ...
Blood Sample Trajectories Years Before Diagnosis Predict Osteoporosis Risk
Repeated pre-diagnostic blood donations from Danish donors reveal that longitudinal metabolite trajectories, particularly declining hippuric acid, predict osteoporosis one to ...
Landmark Trial Pinpoints Which HER2-Positive Breast Cancers Respond to Shorter, Gentler Chemotherapy
Secondary results from the ECOG-ACRIN CompassHER2-pCR trial identify clinical and molecular factors, including HER2DX genomic scores, that predict which stage ...
Immune Blood Markers Offer Rapid Roadmap to Identify Infection Cause and Severity
Researchers at Sun Yat-sen Memorial Hospital have developed a hierarchical diagnostic pathway using cytokines and routine inflammatory markers to rapidly ...
Fifteen-Year Study Reveals How Lipoprotein(a) Levels Shift Over a Lifetime
A 15-year Taiwanese cohort study of 17,363 adults shows lipoprotein(a) levels are largely stable over time, with statin initiation, diabetes, ...
Hourly Blood Urea Nitrogen Patterns Reveal Hidden ICU Death Risk in Bleeding Patients
A multicenter study of nearly 6,000 ICU patients with gastrointestinal bleeding shows that hourly blood urea nitrogen trajectories during the ...
Infrared Light and Metabolomics Point Toward a Faster Fibromyalgia Test
An exploratory study combining infrared spectroscopy with mass spectrometry metabolomics shows that fibromyalgia leaves detectable molecular traces in blood, opening ...
Chemical Tags on Blood Proteins Reveal a New Window Into Alzheimer’s Disease
Researchers at the University of Tokyo have produced the first map of lysine acetylation marks across plasma proteins in Alzheimer's ...
Proteomic Map of Cervical Cancer Reveals Subtypes and a New Drug Target
A large-scale proteomic study of 404 cervical cancer samples has revealed three molecular subtypes of squamous cell carcinoma with distinct ...
Exercise Leaves Distinct Protein Fingerprints in Blood That Track Memory Gains in Older Adults
A twelve-week randomized trial found that aerobic and coordination exercise share a common plasma protein signature while aerobic training adds ...
Ribosomal RNA Passes Its Test as a Steady Reference in High-Throughput Plasma qPCR
A large analysis of FIELD trial plasma samples shows that 18 S rRNA is a technically stable qPCR control that ...
Epigenetic Clocks Stay Ticking in Brain Fluid After Bleeding Stroke
A longitudinal study of 273 stroke patients shows that DNA methylation age measured in cerebrospinal fluid remains stable after aneurysmal ...
How Forensic Scientists Tell Drinking Alcohol From Alcohol Made After Death
A new integrative review in the International Journal of Legal Medicine distills a decade of research into which biological samples ...
Blood Methylation Study Tests Whether ANGPT1 Gene Marks Stroke Risk After Brain Aneurysm Rupture
A two-stage epigenome-wide study of aneurysmal subarachnoid hemorrhage patients found that a promising methylation signal at the ANGPT1 gene flipped ...
New Inflammation-Nutrition Index Shows Promise and Limits in COVID-19 Severity Assessment
A Turkish observational study of 60 COVID-19 patients finds that a composite index combining C-reactive protein, ferritin, and albumin tracks ...
Spinal Fluid Inflammatory Proteins Reveal Why ALS Progresses at Different Speeds
Researchers profiling inflammatory proteins in cerebrospinal fluid have identified a signature, including SIRT2 and MMP-1, that distinguishes slow from fast ...
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