Somatic mutations reveal the ontogeny of microglia in human aging
Microglia are the resident macrophages of the central nervous system1. In mice, microglia seed the brain during embryogenesis and can be maintained throughout life with...
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Cemiplimab and fianlimab with neoadjuvant chemotherapy in early-stage high-risk -negative breast cancer
About the Study: Is combined inhibition of programmed cell death 1 protein (PD-1) and lymphocyte activation gene 3 (LAG-3) added to standard neoadjuvant chemotherapy (NAC)...
Combined phage therapy and faecal microbiota transplantation to treat recurrent urinary tract infection: a case series
McCallin, S., Classen, A.Y., Lieberknecht-Jouy, S.C. et al. Combined phage therapy and faecal microbiota transplantation to treat recurrent urinary tract infection: a case series. Nat...
Representations of the intrinsic value of information in mouse orbitofrontal cortex
Bussell, J.J., Badman, R.P., Márton, D. et al. Representations of the intrinsic value of information in mouse orbitofrontal cortex. Nat Neurosci (2026). https://doi.org/10.1038/s41593-026-02377-y https://doi.org/10.1038/s41593-026-02377-y
Pilot study to validate endothelium collection from pulmonary artery balloon catheter in children
Mathias, M., Sperrazza, C., Salkini, A. et al. Pilot study to validate endothelium collection from pulmonary artery balloon catheter in children. Pediatr Res (2026). https://doi.org/10.1038/s41390-026-05326-4...
Ferroptotic propagation: from single-cell execution to tissue-scale death programs
Tang, D., Kang, R. & Kroemer, G. Ferroptotic propagation: from single-cell execution to tissue-scale death programs. Cell Res (2026). https://doi.org/10.1038/s41422-026-01283-z https://doi.org/10.1038/s41422-026-01283-z
Residential proximity to major roadways and prevalent diabetes in older adults: a cross-sectional study based on CLHLS
Li, Y., Feng, S., Liu, H. et al. Residential proximity to major roadways and prevalent diabetes in older adults: a cross-sectional study based on CLHLS....
Reusability report: Exploring the utility and extensibility of an integrated modelling framework for liquid electrolyte design
Despite rapid advances in machine learning-driven electrolyte design, the robustness, transferability and applicability of existing models remain insufficiently explored. Yang et al. recently introduced a...
Structure-alignment-driven cross-graph modeling for functional RNA design
RNAs are critical for biological processes, and their functions are closely tied to their three-dimensional structures. The design of RNA sequences that fold into target...
Regulation of RNA transcript elongation in metazoans and its relevance to disease
Our understanding of transcript elongation by metazoan RNA polymerase II (Pol II) has grown notably in recent years. Advances in structural biology have defined the...
Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
Leng, F. Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments. Nat Protoc (2026). https://doi.org/10.1038/s41596-026-01423-0 https://doi.org/10.1038/s41596-026-01423-0
Sulfated polysaccharides target RANK Lys97 to inhibit osteoclast differentiation and reverse osteoporosis
Current osteoporosis treatments fail to balance bone resorption and formation. Here we show that engineered 2-N,6-O-sulfated chitosan (26SCS), a synthetic pentasaccharide, restores 115% bone mass...
Expanding the repertoire of chemically induced covalent neoantigens
The ubiquitin–proteasome system generates peptide fragments that are displayed on class I major histocompatibility complex molecules. Hapten-modified peptides, or covalent neoantigens, arise from proteins covalently...
Age- and sex-dependent associations of metabolic syndrome with colorectal cancer in the UK Biobank
Luo, Z., Safizadeh, F., Mandic, M. et al. Age- and sex-dependent associations of metabolic syndrome with colorectal cancer in the UK Biobank. Br J Cancer...
Researchers develop low-noise magnetic sensor with enhanced weak-field detection
image: Harnessing spin-texture dynamics in synthetic ferrimagnets for low-noise, high-sensitivity magnetic sensors view more Credit: WANG Kang Researchers from the High Magnetic Field Laboratory of the...