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	<title>YC-1 &#8211; BIOENGINEER.ORG</title>
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		<title>How Low Oxygen Helps Neuroblastoma Turn Killer T Cells Off</title>
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		<pubDate>Fri, 16 Oct 2026 18:49:01 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[CD8+ T cells]]></category>
		<category><![CDATA[HIF-1α]]></category>
		<category><![CDATA[hypoxia]]></category>
		<category><![CDATA[immune checkpoint]]></category>
		<category><![CDATA[Immunotherapy resistance]]></category>
		<category><![CDATA[Neuroblastoma]]></category>
		<category><![CDATA[PD-1]]></category>
		<category><![CDATA[PD-L1]]></category>
		<category><![CDATA[Pediatric Oncology]]></category>
		<category><![CDATA[T cell dysfunction]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
		<category><![CDATA[YC-1]]></category>
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					<description><![CDATA[New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a process that can be partially reversed by targeting either molecule.]]></description>
		
		
		
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