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	<title>variant effect prediction &#8211; BIOENGINEER.ORG</title>
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		<title>New Scoring Method Pinpoints the Rare Genetic Variants That Matter Most for Common Diseases</title>
		<link>https://bioengineer.org/new-scoring-method-pinpoints-the-rare-genetic-variants-that-matter-most-for-common-diseases/</link>
		
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		<pubDate>Mon, 05 Oct 2026 13:48:36 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[complex traits]]></category>
		<category><![CDATA[exome sequencing]]></category>
		<category><![CDATA[genetic risk]]></category>
		<category><![CDATA[heritability]]></category>
		<category><![CDATA[Machine Learning]]></category>
		<category><![CDATA[missense variants]]></category>
		<category><![CDATA[monogenic disease]]></category>
		<category><![CDATA[population genetics]]></category>
		<category><![CDATA[rare variants]]></category>
		<category><![CDATA[RovHer]]></category>
		<category><![CDATA[UK Biobank]]></category>
		<category><![CDATA[variant effect prediction]]></category>
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					<description><![CDATA[A new heritability-optimized scoring method called RovHer identifies the rare missense variants that explain the most genetic variation in complex traits, outperforming existing predictors by roughly tenfold and flagging carriers at elevated clinical risk.]]></description>
		
		
		
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