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	<title>transcription-replication conflicts &#8211; BIOENGINEER.ORG</title>
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		<title>Dicer: The Timeless Enzyme Behind Life’s Repair Mechanisms</title>
		<link>https://bioengineer.org/dicer-the-timeless-enzyme-behind-lifes-repair-mechanisms/</link>
		
		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Tue, 28 Oct 2025 15:25:04 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[Dicer protein functions]]></category>
		<category><![CDATA[genome stability maintenance]]></category>
		<category><![CDATA[RNA interference mechanisms]]></category>
		<category><![CDATA[transcription-replication conflicts]]></category>
		<category><![CDATA[yeast and human evolution]]></category>
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					<description><![CDATA[In the ever-evolving landscape of molecular biology, the delicate balance between DNA transcription and replication has emerged as a critical frontier in understanding genome integrity. Despite their stark differences in appearance, yeast and humans share a remarkable evolutionary legacy reaching back to their last eukaryotic common ancestor (LECA), dating approximately two billion years ago. This [&#8230;]]]></description>
		
		
		
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		<title>KCTD10 Detects Co-Directional Transcription-Replication Conflicts</title>
		<link>https://bioengineer.org/kctd10-detects-co-directional-transcription-replication-conflicts/</link>
		
		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Wed, 08 Oct 2025 17:47:38 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[co-directional transcription-replication conflicts]]></category>
		<category><![CDATA[CUL3 ubiquitin ligase]]></category>
		<category><![CDATA[DNA replication stress]]></category>
		<category><![CDATA[genome stability]]></category>
		<category><![CDATA[genome stability mechanisms]]></category>
		<category><![CDATA[KCTD10]]></category>
		<category><![CDATA[KCTD10-CUL3 interaction]]></category>
		<category><![CDATA[PCNA-RNA polymerase II complexes]]></category>
		<category><![CDATA[transcription-replication conflicts]]></category>
		<category><![CDATA[ubiquitin-dependent TRC resolution]]></category>
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					<description><![CDATA[In a groundbreaking study poised to reshape our understanding of how cells preserve genomic integrity during DNA replication, researchers have identified KCTD10 as a critical sensor and facilitator in the resolution of transcription–replication conflicts (TRCs). These conflicts, often occurring when the machinery responsible for copying DNA collides with the transcription apparatus that reads DNA to [&#8230;]]]></description>
		
		
		
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