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	<title>TL1A &#8211; BIOENGINEER.ORG</title>
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		<title>Dual-Target Antibody Strikes Two Inflammatory Pathways to Ease Colitis in Mice</title>
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		<pubDate>Mon, 12 Oct 2026 15:23:59 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[bispecific antibody]]></category>
		<category><![CDATA[colitis]]></category>
		<category><![CDATA[DR3]]></category>
		<category><![CDATA[FcRn]]></category>
		<category><![CDATA[half-life extension]]></category>
		<category><![CDATA[IL-12/23p40]]></category>
		<category><![CDATA[inflammatory bowel disease]]></category>
		<category><![CDATA[preclinical study]]></category>
		<category><![CDATA[STAT3]]></category>
		<category><![CDATA[Th1 cells]]></category>
		<category><![CDATA[Th17 cells]]></category>
		<category><![CDATA[TL1A]]></category>
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					<description><![CDATA[Scientists have engineered a bispecific antibody that simultaneously blocks TL1A and IL-12/23p40, suppressing pathogenic Th1/Th17 immune responses and significantly ameliorating colitis in humanized mice.]]></description>
		
		
		
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