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	<title>therapeutics &#8211; BIOENGINEER.ORG</title>
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		<title>Human 3D Tumor Assembloids Reveal How Targeted Interferon-Gamma Therapies Could Outsmart the Tumor Microenvironment</title>
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		<pubDate>Fri, 16 Oct 2026 13:58:43 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[assembloids]]></category>
		<category><![CDATA[Cancer immunotherapy]]></category>
		<category><![CDATA[Cancer-associated fibroblasts]]></category>
		<category><![CDATA[Colorectal cancer]]></category>
		<category><![CDATA[cytokine-based]]></category>
		<category><![CDATA[Evaluating]]></category>
		<category><![CDATA[human]]></category>
		<category><![CDATA[interferon-gamma]]></category>
		<category><![CDATA[organoids]]></category>
		<category><![CDATA[targeted cytokines]]></category>
		<category><![CDATA[therapeutics]]></category>
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					<description><![CDATA[Roche researchers validate a human 3D immune-containing colorectal cancer assembloid platform that captures interferon-gamma signaling, uncovers fibroblast plasticity, and demonstrates that FAP-targeted cytokine molecules can retain anti-tumor activity while avoiding PD-L1-mediated immunosuppression.]]></description>
		
		
		
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