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	<title>T-cell engager &#8211; BIOENGINEER.ORG</title>
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		<title>AI-Designed Protein Drug Recruits Immune Cells to Fight Gastric Cancer—With a Helping Hand from Dendritic Cells</title>
		<link>https://bioengineer.org/ai-designed-protein-drug-recruits-immune-cells-to-fight-gastric-cancer-with-a-helping-hand-from-dendritic-cells/</link>
		
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		<pubDate>Fri, 09 Oct 2026 22:22:04 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[CLDN18.2]]></category>
		<category><![CDATA[CXCL10]]></category>
		<category><![CDATA[CXCL9]]></category>
		<category><![CDATA[dendritic cells]]></category>
		<category><![CDATA[gastric cancer]]></category>
		<category><![CDATA[IL-12]]></category>
		<category><![CDATA[immunotherapy]]></category>
		<category><![CDATA[organoids]]></category>
		<category><![CDATA[patient-derived xenografts]]></category>
		<category><![CDATA[Protein Design]]></category>
		<category><![CDATA[RFdiffusion]]></category>
		<category><![CDATA[T-cell engager]]></category>
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					<description><![CDATA[A team at Nanjing Medical University used RFdiffusion to design a CLDN18.2-targeting T-cell engager for gastric cancer and showed that dendritic-cell supplementation via IL-12 and CXCL9/CXCL10 signaling is needed for durable antitumor responses.]]></description>
		
		
		
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