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		<title>Gene disruption yields new anthraquinone analogue with antibacterial and antimalarial activity</title>
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		<pubDate>Tue, 27 Oct 2026 16:11:15 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[anthraquinones]]></category>
		<category><![CDATA[antibacterial activity]]></category>
		<category><![CDATA[Antimalarial activity]]></category>
		<category><![CDATA[Biosynthetic gene cluster]]></category>
		<category><![CDATA[cytotoxicity]]></category>
		<category><![CDATA[drug discovery]]></category>
		<category><![CDATA[gene disruption]]></category>
		<category><![CDATA[kinanthraquinone]]></category>
		<category><![CDATA[natural products]]></category>
		<category><![CDATA[O-methyltransferase]]></category>
		<category><![CDATA[Streptomyces lividans]]></category>
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					<description><![CDATA[Researchers disrupted an O-methyltransferase gene in the kinanthraquinone biosynthetic cluster and isolated a new demethylated analogue whose activities reveal how C-5 methylation shapes antibacterial and cytotoxic effects.]]></description>
		
		
		
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