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	<title>stromal fibrosis &#8211; BIOENGINEER.ORG</title>
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		<title>Collagen Clue: How COL6A1 May Drive Bile Duct Cancer&#8217;s Deadly Spread</title>
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		<pubDate>Sat, 10 Oct 2026 16:58:17 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[bile duct cancer]]></category>
		<category><![CDATA[biomarker]]></category>
		<category><![CDATA[Cancer-associated fibroblasts]]></category>
		<category><![CDATA[cholangiocarcinoma]]></category>
		<category><![CDATA[COL6A1]]></category>
		<category><![CDATA[drug resistance]]></category>
		<category><![CDATA[extracellular matrix]]></category>
		<category><![CDATA[immune evasion]]></category>
		<category><![CDATA[PI3K/Akt signaling]]></category>
		<category><![CDATA[stromal fibrosis]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[A new review in Cancer Reports proposes that the extracellular matrix protein COL6A1, overexpressed in the fibrotic stroma of cholangiocarcinoma, may drive tumor progression through matrix remodeling, fibroblast activation, immune suppression, and drug resistance.]]></description>
		
		
		
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