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	<title>STING pathway activation &#8211; BIOENGINEER.ORG</title>
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	<title>STING pathway activation &#8211; BIOENGINEER.ORG</title>
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		<title>PLD4 Mutations Trigger Systemic Lupus Erythematosus</title>
		<link>https://bioengineer.org/pld4-mutations-trigger-systemic-lupus-erythematosus/</link>
		
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		<pubDate>Wed, 10 Sep 2025 21:49:29 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Mitochondrial DNA leakage]]></category>
		<category><![CDATA[PLD4 mutations]]></category>
		<category><![CDATA[STING pathway activation]]></category>
		<category><![CDATA[STING pathway hyperactivation]]></category>
		<category><![CDATA[systemic lupus erythematosus]]></category>
		<category><![CDATA[type I interferon overproduction]]></category>
		<category><![CDATA[Type I interferon signaling]]></category>
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					<description><![CDATA[A newly published study in Nature unveils a critical nexus between PLD4 deficiency and aberrant immune activation, shedding light on the molecular underpinnings of systemic lupus erythematosus (SLE). Researchers have discovered that loss-of-function mutations in the phospholipase D4 (PLD4) gene provoke hyperactivation of the STING-dependent signaling cascade, particularly the type I interferon (IFN) pathway, which [&#8230;]]]></description>
		
		
		
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