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	<title>SPP1 macrophages &#8211; BIOENGINEER.ORG</title>
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		<title>Hidden Immune Saboteurs: Scientists Map the Cells That Shield Colorectal Tumors</title>
		<link>https://bioengineer.org/hidden-immune-saboteurs-scientists-map-the-cells-that-shield-colorectal-tumors/</link>
		
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		<pubDate>Fri, 09 Oct 2026 01:33:59 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[CCL18-CCR8 signaling]]></category>
		<category><![CDATA[Colorectal cancer]]></category>
		<category><![CDATA[IFI6]]></category>
		<category><![CDATA[immune evasion]]></category>
		<category><![CDATA[immunotherapy]]></category>
		<category><![CDATA[LGALS9]]></category>
		<category><![CDATA[regulatory T cells]]></category>
		<category><![CDATA[single-cell RNA sequencing]]></category>
		<category><![CDATA[Spatial transcriptomics]]></category>
		<category><![CDATA[SPP1 macrophages]]></category>
		<category><![CDATA[tertiary lymphoid structures]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[By combining spatial and single-cell transcriptomics, researchers have mapped previously unknown immunosuppressive niches in colorectal cancer, including SPP1-positive macrophage rings and a novel IFI6-positive regulatory T cell population linked to poor survival and therapy resistance.]]></description>
		
		
		
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