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	<title>SIRD model &#8211; BIOENGINEER.ORG</title>
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		<title>Decades-Old Smallpox Shots Leave Fading Immunity, With Chronic Illness Weakening the Shield</title>
		<link>https://bioengineer.org/decades-old-smallpox-shots-leave-fading-immunity-with-chronic-illness-weakening-the-shield/</link>
		
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		<pubDate>Wed, 07 Oct 2026 23:04:15 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[antibody titers]]></category>
		<category><![CDATA[cellular immunity]]></category>
		<category><![CDATA[chronic disease]]></category>
		<category><![CDATA[humoral immunity]]></category>
		<category><![CDATA[immunocompromised]]></category>
		<category><![CDATA[mpox]]></category>
		<category><![CDATA[neutralizing antibodies]]></category>
		<category><![CDATA[orthopoxvirus]]></category>
		<category><![CDATA[outbreak modeling]]></category>
		<category><![CDATA[SIRD model]]></category>
		<category><![CDATA[smallpox vaccination]]></category>
		<category><![CDATA[vaccinia virus]]></category>
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					<description><![CDATA[A large study of historically smallpox-vaccinated individuals finds residual but uneven immunity, with chronic disease and cancer linked to lower antibody levels, and exploratory modeling suggests immunocompromised groups could face distinct infection and mortality patterns in hypothetical orthopoxvirus outbreaks.]]></description>
		
		
		
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