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	<title>single-molecule FRET &#8211; BIOENGINEER.ORG</title>
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		<title>Opioid drugs reach deep into their G proteins, single-molecule study reveals</title>
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		<pubDate>Tue, 13 Oct 2026 21:11:57 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[allostery]]></category>
		<category><![CDATA[buprenorphine]]></category>
		<category><![CDATA[conformational dynamics]]></category>
		<category><![CDATA[G protein]]></category>
		<category><![CDATA[GDP release]]></category>
		<category><![CDATA[GPCR]]></category>
		<category><![CDATA[nucleotide exchange]]></category>
		<category><![CDATA[opioid efficacy]]></category>
		<category><![CDATA[pharmacology]]></category>
		<category><![CDATA[single-molecule FRET]]></category>
		<category><![CDATA[structural biology]]></category>
		<category><![CDATA[μ-opioid receptor]]></category>
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					<description><![CDATA[Single-molecule FRET imaging shows that opioid ligands allosterically tune the conformational dynamics of bound G proteins over 70 angstroms away, providing a new mechanism for encoding drug efficacy.]]></description>
		
		
		
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