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		<title>Disc Degeneration Traced to a Histone Switch That Silences the Cell&#8217;s Mitochondrial Cleanup Crew</title>
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		<pubDate>Wed, 14 Oct 2026 13:12:01 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[Apoptosis]]></category>
		<category><![CDATA[back pain]]></category>
		<category><![CDATA[CBX3]]></category>
		<category><![CDATA[epigenetics]]></category>
		<category><![CDATA[extracellular matrix]]></category>
		<category><![CDATA[H3K9me3]]></category>
		<category><![CDATA[intervertebral disc degeneration]]></category>
		<category><![CDATA[Mitophagy]]></category>
		<category><![CDATA[nucleus pulposus cells]]></category>
		<category><![CDATA[Parkin]]></category>
		<category><![CDATA[PINK1]]></category>
		<category><![CDATA[SESN2]]></category>
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					<description><![CDATA[A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, disabling PINK1-Parkin mitophagy and driving nucleus pulposus cell death.]]></description>
		
		
		
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