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	<title>Safety-by-Design &#8211; BIOENGINEER.ORG</title>
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		<title>Computational Framework Ranks Safer RNA-LNP Formulations Before the Lab</title>
		<link>https://bioengineer.org/computational-framework-ranks-safer-rna-lnp-formulations-before-the-lab/</link>
		
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		<pubDate>Sun, 04 Oct 2026 19:32:11 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[drug safety]]></category>
		<category><![CDATA[Explainable Artificial Intelligence]]></category>
		<category><![CDATA[lipid nanoparticles]]></category>
		<category><![CDATA[mechanistic modeling]]></category>
		<category><![CDATA[Pareto optimization]]></category>
		<category><![CDATA[Random Forest]]></category>
		<category><![CDATA[RNA therapeutics**]]></category>
		<category><![CDATA[Safety-by-Design]]></category>
		<category><![CDATA[single-cell RNA sequencing]]></category>
		<category><![CDATA[synthetic multi-omics]]></category>
		<category><![CDATA[systems immunology]]></category>
		<category><![CDATA[virtual patients]]></category>
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					<description><![CDATA[Researchers at the University of Catania have built a modular computational framework that ranks RNA-lipid nanoparticle formulations for safety and efficacy before any laboratory testing, using virtual patients, machine learning, and a mechanistic check against human single-cell data.]]></description>
		
		
		
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