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		<title>Lactate tag on RPA1 drives DNA repair and breast cancer chemoresistance</title>
		<link>https://bioengineer.org/lactate-tag-on-rpa1-drives-dna-repair-and-breast-cancer-chemoresistance/</link>
		
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		<pubDate>Tue, 27 Oct 2026 14:04:44 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[ATM kinase]]></category>
		<category><![CDATA[Breast Cancer]]></category>
		<category><![CDATA[cell-penetrating peptide]]></category>
		<category><![CDATA[chemoresistance]]></category>
		<category><![CDATA[DNA double-strand break repair]]></category>
		<category><![CDATA[homologous recombination]]></category>
		<category><![CDATA[KAT8]]></category>
		<category><![CDATA[lactate dehydrogenase]]></category>
		<category><![CDATA[lysine lactylation]]></category>
		<category><![CDATA[Olaparib]]></category>
		<category><![CDATA[patient-derived xenograft]]></category>
		<category><![CDATA[RPA1]]></category>
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					<description><![CDATA[Researchers report that lactate-driven lactylation of the DNA repair protein RPA1 at lysine 167, catalyzed by KAT8 after ATM phosphorylation, promotes homologous recombination and chemoresistance in breast cancer models, and that a blocking peptide resensitizes tumors to olaparib.]]></description>
		
		
		
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