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		<title>Massive Parkinson&#8217;s Genetics Study Confirms Rare Gene Variants Raise Disease Risk</title>
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		<pubDate>Fri, 09 Oct 2026 06:13:59 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[GBA1]]></category>
		<category><![CDATA[genetic counseling]]></category>
		<category><![CDATA[Genetics]]></category>
		<category><![CDATA[haploinsufficiency]]></category>
		<category><![CDATA[ITSN1]]></category>
		<category><![CDATA[loss-of-function variants]]></category>
		<category><![CDATA[LRRK2]]></category>
		<category><![CDATA[Mendelian inheritance]]></category>
		<category><![CDATA[neurodevelopmental disorders]]></category>
		<category><![CDATA[Parkinson’s disease]]></category>
		<category><![CDATA[reduced penetrance]]></category>
		<category><![CDATA[ROPAD study]]></category>
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					<description><![CDATA[New data from the 8,660-participant ROPAD cohort corroborate that ITSN1 loss-of-function variants raise Parkinson's disease risk five- to fifteen-fold, while French researchers argue key questions about inheritance, penetrance, and counseling remain open.]]></description>
		
		
		
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