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	<title>radiation sensitivity &#8211; BIOENGINEER.ORG</title>
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		<title>Targeting ESR1 Reactivates Autophagy, Boosts Breast Cancer Sensitivity</title>
		<link>https://bioengineer.org/targeting-esr1-reactivates-autophagy-boosts-breast-cancer-sensitivity/</link>
		
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		<pubDate>Tue, 07 Oct 2025 14:38:23 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[autophagy reactivation]]></category>
		<category><![CDATA[autophagy reactivation in breast cancer]]></category>
		<category><![CDATA[ER-positive breast cancer]]></category>
		<category><![CDATA[ER-positive breast cancer therapy]]></category>
		<category><![CDATA[ESR1 targeting]]></category>
		<category><![CDATA[oxidative stress therapy]]></category>
		<category><![CDATA[p62/SQSTM1 pathway]]></category>
		<category><![CDATA[radiation sensitivity]]></category>
		<category><![CDATA[therapeutic resistance mechanisms]]></category>
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					<description><![CDATA[In a groundbreaking advance that could reshape the therapeutic landscape for estrogen receptor-positive (ER-positive) breast cancer, researchers have unraveled a novel mechanism that links estrogen receptor signaling to autophagic regulation, opening new avenues to intensify the sensitivity of cancer cells to oxidative and radiation-induced stress. This breakthrough study reveals how targeting ESR1—the gene encoding estrogen [&#8230;]]]></description>
		
		
		
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