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		<title>Low pyruvate carboxylase makes respiration-deficient tumours dependent on asparagine</title>
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		<pubDate>Tue, 27 Oct 2026 10:58:53 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[asparagine auxotrophy]]></category>
		<category><![CDATA[aspartate metabolism]]></category>
		<category><![CDATA[ATF4]]></category>
		<category><![CDATA[GCN2]]></category>
		<category><![CDATA[heteroplasmy]]></category>
		<category><![CDATA[integrated stress response]]></category>
		<category><![CDATA[L-asparaginase]]></category>
		<category><![CDATA[mitochondrial DNA]]></category>
		<category><![CDATA[oxidative phosphorylation]]></category>
		<category><![CDATA[pyruvate carboxylase]]></category>
		<category><![CDATA[Thyroid cancer]]></category>
		<category><![CDATA[xenograft]]></category>
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					<description><![CDATA[A Nature Metabolism study shows that respiration-deficient cells with low pyruvate carboxylase become dependent on asparagine, a vulnerability exploited by L-asparaginase in thyroid cancer models.]]></description>
		
		
		
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