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		<title>Famed brain cancer drug turns out to hit a metabolic enzyme, not its intended target</title>
		<link>https://bioengineer.org/famed-brain-cancer-drug-turns-out-to-hit-a-metabolic-enzyme-not-its-intended-target/</link>
		
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		<pubDate>Thu, 08 Oct 2026 22:04:46 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[cancer metabolism]]></category>
		<category><![CDATA[Chemical probes]]></category>
		<category><![CDATA[CRISPR Screens]]></category>
		<category><![CDATA[DHODH]]></category>
		<category><![CDATA[drug mechanism]]></category>
		<category><![CDATA[epigenetics]]></category>
		<category><![CDATA[Glioblastoma]]></category>
		<category><![CDATA[KDM4]]></category>
		<category><![CDATA[pyrimidine biosynthesis]]></category>
		<category><![CDATA[QC6352]]></category>
		<category><![CDATA[target deconvolution]]></category>
		<category><![CDATA[zavondemstat]]></category>
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					<description><![CDATA[A comprehensive chemical biology study shows that the celebrated KDM4 inhibitor QC6352 and its clinical analog zavondemstat kill glioblastoma stem cells primarily by blocking the pyrimidine-synthesis enzyme DHODH, not the epigenetic enzymes they were designed to target.]]></description>
		
		
		
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