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		<title>Lactate Marks on Histones Drive Wilms Tumor Growth Through a Self-Reinforcing Genetic Loop</title>
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				<category><![CDATA[Technology]]></category>
		<category><![CDATA[AKT signaling]]></category>
		<category><![CDATA[epigenetics]]></category>
		<category><![CDATA[H3K18la]]></category>
		<category><![CDATA[HIF-1α]]></category>
		<category><![CDATA[Histone lactylation]]></category>
		<category><![CDATA[Metabolic Reprogramming]]></category>
		<category><![CDATA[p300]]></category>
		<category><![CDATA[Pediatric cancer]]></category>
		<category><![CDATA[PSRC1]]></category>
		<category><![CDATA[PTEN]]></category>
		<category><![CDATA[Warburg Effect]]></category>
		<category><![CDATA[Wilms tumor]]></category>
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					<description><![CDATA[New research reveals that lactate-driven histone H3K18 lactylation activates a PSRC1/AKT/HIF-1α positive feedback loop that propels the malignant progression of Wilms tumor, the most common childhood kidney cancer.]]></description>
		
		
		
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