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	<title>protofibrillar tau cerebrovascular effects &#8211; BIOENGINEER.ORG</title>
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		<title>Researchers at Lewis Katz School of Medicine Reveal How Tau Protein Compromises Brain Vascular Defenses in Alzheimer’s Disease</title>
		<link>https://bioengineer.org/researchers-at-lewis-katz-school-of-medicine-reveal-how-tau-protein-compromises-brain-vascular-defenses-in-alzheimers-disease/</link>
		
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		<pubDate>Tue, 29 Apr 2025 20:38:01 +0000</pubDate>
				<category><![CDATA[Chemistry]]></category>
		<category><![CDATA[Alzheimer's neurovascular intervention strategies]]></category>
		<category><![CDATA[blood-brain barrier dysfunction Alzheimer's]]></category>
		<category><![CDATA[neurovascular metabolic alterations]]></category>
		<category><![CDATA[protofibrillar tau cerebrovascular effects]]></category>
		<category><![CDATA[tau-mediated vascular injury]]></category>
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					<description><![CDATA[Tau protein has long been implicated in the characteristic neurofibrillary tangles found in Alzheimer’s disease, predominantly associated with neuronal damage and cognitive decline. However, recent histopathological observations have detected accumulations of tau aggregates not only within neural tissue but distinctly localized along the cerebrovascular endothelium. This vascular tau deposition has eluded mechanistic understanding until now, [&#8230;]]]></description>
		
		
		
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