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	<title>presymptomatic disease &#8211; BIOENGINEER.ORG</title>
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		<title>Subtle cognitive deficits emerge before ALS symptoms appear, study finds</title>
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		<pubDate>Sun, 25 Oct 2026 04:52:13 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[ALS]]></category>
		<category><![CDATA[biomarkers]]></category>
		<category><![CDATA[C9ORF72]]></category>
		<category><![CDATA[executive function]]></category>
		<category><![CDATA[frontotemporal dementia]]></category>
		<category><![CDATA[genetic carriers]]></category>
		<category><![CDATA[mild cognitive impairment]]></category>
		<category><![CDATA[neuropsychology]]></category>
		<category><![CDATA[phenoconversion]]></category>
		<category><![CDATA[Pre-fALS study]]></category>
		<category><![CDATA[presymptomatic disease]]></category>
		<category><![CDATA[SOD1]]></category>
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					<description><![CDATA[A longitudinal study of people carrying ALS genetic variants found mild cognitive impairment, mainly affecting language and executive functioning, in 20 percent of presymptomatic C9ORF72 carriers and 13 percent of SOD1 carriers before any motor symptoms appeared.]]></description>
		
		
		
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