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		<title>Aging-like B cells emerge as hidden drivers of rheumatoid arthritis onset</title>
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		<pubDate>Thu, 15 Oct 2026 01:18:03 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[ACPA]]></category>
		<category><![CDATA[antigen presentation]]></category>
		<category><![CDATA[autoimmunity]]></category>
		<category><![CDATA[B cells]]></category>
		<category><![CDATA[citrullinated antigens]]></category>
		<category><![CDATA[disease prevention]]></category>
		<category><![CDATA[immune aging]]></category>
		<category><![CDATA[preclinical disease]]></category>
		<category><![CDATA[Rheumatoid arthritis]]></category>
		<category><![CDATA[Senescence]]></category>
		<category><![CDATA[single-cell multiomics]]></category>
		<category><![CDATA[T Cells]]></category>
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					<description><![CDATA[Single-cell multiomics reveals that people who progress from ACPA-positive at-risk status to clinical rheumatoid arthritis carry an expansion of senescent-like activated naive B cells that express polyreactive autoreactive antibodies and present self-antigens to T cells.]]></description>
		
		
		
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