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	<title>PM-13 gene signature &#8211; BIOENGINEER.ORG</title>
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		<title>Exploding immune cells may explain why prostate drug therapy fails in some men</title>
		<link>https://bioengineer.org/exploding-immune-cells-may-explain-why-prostate-drug-therapy-fails-in-some-men/</link>
		
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		<pubDate>Thu, 08 Oct 2026 14:30:29 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[5-alpha-reductase inhibitors]]></category>
		<category><![CDATA[Benign Prostatic Hyperplasia]]></category>
		<category><![CDATA[Cellular Senescence]]></category>
		<category><![CDATA[club-cell reprogramming]]></category>
		<category><![CDATA[GSDMD]]></category>
		<category><![CDATA[HMGB1–AGER signaling]]></category>
		<category><![CDATA[macrophage pyroptosis]]></category>
		<category><![CDATA[MIF–CD74 axis]]></category>
		<category><![CDATA[Notch Signaling]]></category>
		<category><![CDATA[PM-13 gene signature]]></category>
		<category><![CDATA[single-cell RNA sequencing]]></category>
		<category><![CDATA[Spatial transcriptomics]]></category>
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					<description><![CDATA[A new study shows that 5-alpha-reductase inhibitor therapy can trigger macrophage pyroptosis, HMGB1–AGER-driven epithelial senescence and club-cell reprogramming in the prostate, explaining why some patients with benign prostatic hyperplasia progress despite treatment.]]></description>
		
		
		
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