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	<title>p53-p21 pathway &#8211; BIOENGINEER.ORG</title>
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		<title>The Dark Side of Good Cholesterol: Rogue HDL Particle Drives Arterial Aging</title>
		<link>https://bioengineer.org/the-dark-side-of-good-cholesterol-rogue-hdl-particle-drives-arterial-aging/</link>
		
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		<pubDate>Tue, 06 Oct 2026 15:07:37 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[apolipoprotein(a)]]></category>
		<category><![CDATA[Atherosclerosis]]></category>
		<category><![CDATA[Cardiovascular disease]]></category>
		<category><![CDATA[carotid intima-media thickness]]></category>
		<category><![CDATA[cholesterol efflux]]></category>
		<category><![CDATA[endothelial senescence]]></category>
		<category><![CDATA[H5 subfraction]]></category>
		<category><![CDATA[HDL]]></category>
		<category><![CDATA[metabolic syndrome]]></category>
		<category><![CDATA[p53-p21 pathway]]></category>
		<category><![CDATA[reactive oxygen species]]></category>
		<category><![CDATA[Vascular aging]]></category>
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					<description><![CDATA[Scientists have identified an electronegative HDL subfraction enriched in apolipoprotein(a) that induces endothelial senescence through the p53–p21 pathway and accelerates atherosclerosis, suggesting HDL quality rather than quantity should be the target of new therapies.]]></description>
		
		
		
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