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		<title>When Chromatin Wobbles, Cells Pay a Metabolic Price, Study Finds</title>
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		<pubDate>Sat, 10 Oct 2026 12:42:48 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[chromatin]]></category>
		<category><![CDATA[histone degradation]]></category>
		<category><![CDATA[histone H3]]></category>
		<category><![CDATA[metabolic stress]]></category>
		<category><![CDATA[mitochondria]]></category>
		<category><![CDATA[nutrient signaling]]></category>
		<category><![CDATA[OXPHOS]]></category>
		<category><![CDATA[PLOS Genetics]]></category>
		<category><![CDATA[reactive oxygen species]]></category>
		<category><![CDATA[retrograde signaling]]></category>
		<category><![CDATA[TORC1]]></category>
		<category><![CDATA[yeast genetics]]></category>
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					<description><![CDATA[A PLOS Genetics study shows that destabilizing chromatin through a histone H3 mutation hyperactivates the nutrient-sensing TORC1 pathway and triggers lethal mitochondrial dysfunction when TORC1 is inhibited, revealing bidirectional signaling between chromatin and metabolism.]]></description>
		
		
		
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