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	<title>OVOL2 &#8211; BIOENGINEER.ORG</title>
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	<title>OVOL2 &#8211; BIOENGINEER.ORG</title>
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		<title>Lactate Tags a Tumor Suppressor and Fuels Liver Cancer Growth</title>
		<link>https://bioengineer.org/lactate-tags-a-tumor-suppressor-and-fuels-liver-cancer-growth/</link>
		
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		<pubDate>Sun, 04 Oct 2026 10:47:19 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[cancer metabolism]]></category>
		<category><![CDATA[cell-penetrating peptide]]></category>
		<category><![CDATA[Hepatocellular Carcinoma]]></category>
		<category><![CDATA[KAT8]]></category>
		<category><![CDATA[lactylation]]></category>
		<category><![CDATA[liver cancer]]></category>
		<category><![CDATA[OVOL2]]></category>
		<category><![CDATA[post-translational modification]]></category>
		<category><![CDATA[RBM47]]></category>
		<category><![CDATA[TRIM54]]></category>
		<category><![CDATA[Tumor Suppressor]]></category>
		<category><![CDATA[Ubiquitination]]></category>
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					<description><![CDATA[Researchers report that lactate-driven lactylation of the tumor suppressor OVOL2 at lysine 3, catalyzed by KAT8, weakens its nuclear function and unleashes a TRIM54-RBM47 degradation pathway that promotes hepatocellular carcinoma growth, which a cell-penetrating peptide blocked in animal models.]]></description>
		
		
		
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