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		<title>Synthetic Sequences Are Not the Whole Story Behind Engineered LINE-1 Retrotransposition</title>
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		<pubDate>Sat, 17 Oct 2026 12:09:12 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[3'UTR]]></category>
		<category><![CDATA[codon optimization]]></category>
		<category><![CDATA[G-quadruplex]]></category>
		<category><![CDATA[gene expression]]></category>
		<category><![CDATA[genome engineering]]></category>
		<category><![CDATA[LINE-1]]></category>
		<category><![CDATA[mouse genome]]></category>
		<category><![CDATA[ORF1p]]></category>
		<category><![CDATA[PLOS Genetics]]></category>
		<category><![CDATA[retrotransposition]]></category>
		<category><![CDATA[synthetic biology]]></category>
		<category><![CDATA[transposable elements]]></category>
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					<description><![CDATA[A new PLOS Genetics study shows that two unintended sequence changes, not synthetic codon optimization, explain the enhanced retrotransposition of a widely used engineered mouse LINE-1 element.]]></description>
		
		
		
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