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	<title>ORC1 &#8211; BIOENGINEER.ORG</title>
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		<title>ORC1: The Replication Gatekeeper Linking Genome Stability to Cancer</title>
		<link>https://bioengineer.org/orc1-the-replication-gatekeeper-linking-genome-stability-to-cancer/</link>
		
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		<pubDate>Tue, 13 Oct 2026 18:34:44 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[cancer]]></category>
		<category><![CDATA[cell cycle]]></category>
		<category><![CDATA[chromatin remodeling]]></category>
		<category><![CDATA[DNA replication]]></category>
		<category><![CDATA[genomic stability]]></category>
		<category><![CDATA[helicase loading]]></category>
		<category><![CDATA[Journal of Translational Medicine]]></category>
		<category><![CDATA[ORC1]]></category>
		<category><![CDATA[origin licensing]]></category>
		<category><![CDATA[origin recognition complex]]></category>
		<category><![CDATA[Precision Medicine]]></category>
		<category><![CDATA[small molecule inhibitors]]></category>
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					<description><![CDATA[A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards genome stability and why its dysregulation is implicated in cancer, while cautioning that ORC1-directed therapies still await clinical validation.]]></description>
		
		
		
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