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	<title>oncometabolites &#8211; BIOENGINEER.ORG</title>
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		<title>Cancer Cells Rewire Immune Neutrophils Through a Fumarate-Driven Metabolic Switch, Study Finds</title>
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		<pubDate>Tue, 06 Oct 2026 12:34:38 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[Colorectal cancer]]></category>
		<category><![CDATA[epigenetics]]></category>
		<category><![CDATA[ferroptosis]]></category>
		<category><![CDATA[fumarate]]></category>
		<category><![CDATA[GSK3β]]></category>
		<category><![CDATA[immunotherapy]]></category>
		<category><![CDATA[lactylation]]></category>
		<category><![CDATA[neutrophils]]></category>
		<category><![CDATA[oncometabolites]]></category>
		<category><![CDATA[PD-L1]]></category>
		<category><![CDATA[tideglusib]]></category>
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					<description><![CDATA[A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms neutrophils into immunosuppressive cells, and shows that blocking this pathway with tideglusib enhances immunotherapy in preclinical models.]]></description>
		
		
		
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