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	<title>nuclear localization &#8211; BIOENGINEER.ORG</title>
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		<title>Sticky Tags on a Viral Enzyme: SUMOylation Steers Herpesvirus Thymidine Kinase Into Neurons</title>
		<link>https://bioengineer.org/sticky-tags-on-a-viral-enzyme-sumoylation-steers-herpesvirus-thymidine-kinase-into-neurons/</link>
		
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		<pubDate>Sat, 10 Oct 2026 18:53:40 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[Health]]></category>
		<category><![CDATA[alphaherpesvirus]]></category>
		<category><![CDATA[antiviral targets]]></category>
		<category><![CDATA[latency]]></category>
		<category><![CDATA[neuronal replication]]></category>
		<category><![CDATA[nuclear localization]]></category>
		<category><![CDATA[PLOS Pathogens]]></category>
		<category><![CDATA[post-translational modification]]></category>
		<category><![CDATA[pseudorabies virus]]></category>
		<category><![CDATA[SUMOylation]]></category>
		<category><![CDATA[thymidine kinase]]></category>
		<category><![CDATA[UL23]]></category>
		<category><![CDATA[viral reactivation]]></category>
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					<description><![CDATA[Researchers report that SUMOylation of pseudorabies virus thymidine kinase at two lysine residues controls the enzyme's nuclear localization, enabling efficient neuronal replication, viral reactivation, and full pathogenicity.]]></description>
		
		
		
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