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	<title>Notch signaling pathway activation &#8211; BIOENGINEER.ORG</title>
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		<title>AI-Driven Protein Design Advances T-Cell Immunotherapy Breakthroughs</title>
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		<pubDate>Fri, 01 Aug 2025 21:15:21 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[AI-driven protein design]]></category>
		<category><![CDATA[immune response enhancement]]></category>
		<category><![CDATA[Notch signaling pathway activation]]></category>
		<category><![CDATA[synthetic ligand development]]></category>
		<category><![CDATA[T-cell immunotherapy advancements]]></category>
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					<description><![CDATA[In a groundbreaking advancement published in the prestigious journal Cell, scientists have unveiled a revolutionary synthetic ligand capable of activating the Notch signaling pathway, a critical regulator in T-cell development and immune function. This pioneering work harnesses state-of-the-art AI-driven computational protein design to engineer soluble Notch agonists that can be applied to optimize clinical T-cell [&#8230;]]]></description>
		
		
		
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