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	<title>neonatal seizures &#8211; BIOENGINEER.ORG</title>
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	<title>neonatal seizures &#8211; BIOENGINEER.ORG</title>
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		<title>NMDA receptors play an important role in postictal potentiation in immature rats</title>
		<link>https://bioengineer.org/nmda-receptors-play-an-important-role-in-postictal-potentiation-in-immature-rats/</link>
		
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		<pubDate>Sat, 17 Oct 2026 14:01:58 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[AMPA receptors]]></category>
		<category><![CDATA[developing brain]]></category>
		<category><![CDATA[epilepsy]]></category>
		<category><![CDATA[GluN2B subunit]]></category>
		<category><![CDATA[glutamate receptors]]></category>
		<category><![CDATA[neonatal seizures]]></category>
		<category><![CDATA[NMDA]]></category>
		<category><![CDATA[NMDA receptors]]></category>
		<category><![CDATA[postictal potentiation]]></category>
		<category><![CDATA[receptors]]></category>
		<category><![CDATA[status epilepticus]]></category>
		<category><![CDATA[synaptic neuroscience]]></category>
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					<description><![CDATA[Neonatal seizures remain one of the most stubborn challenges in clinical neurology. The highest prevalence of seizures in humans occurs during the neonatal period, a phase of brain development in which excitation dominates over inhibition. That dominance of excitation is believed to be essential for the rapid pace of early brain development, but it also renders the immature brain highly vulnerable to seizures and status epilepticus. Therapies that work in older children and adults, including phenobarbital, the drug recommended by expert groups for neonates, are largely ineffective in newborns, most likely because the neuronal mechanisms underlying hyperexcitability at this stage are fundamentally different. A new study published in Frontiers in Synaptic Neuroscience by Pavel Mares of the Institute of Physiology of the Czech Academy of Sciences, James L. Burchfiel of the University of Rochester, and Hana Kubova of the Czech Academy of Sciences now offers a detailed pharmacological disse]]></description>
		
		
		
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