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	<title>NECAP2 &#8211; BIOENGINEER.ORG</title>
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		<title>Hidden LRRK2 Overactivity Found in Parkinson&#8217;s Patients Without Known Mutations</title>
		<link>https://bioengineer.org/hidden-lrrk2-overactivity-found-in-parkinsons-patients-without-known-mutations/</link>
		
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		<pubDate>Thu, 08 Oct 2026 23:19:16 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Genetic modifiers]]></category>
		<category><![CDATA[kinase activity]]></category>
		<category><![CDATA[LRRK2]]></category>
		<category><![CDATA[NECAP2]]></category>
		<category><![CDATA[neutrophils]]></category>
		<category><![CDATA[Parkinson’s disease]]></category>
		<category><![CDATA[patient stratification]]></category>
		<category><![CDATA[Precision Medicine]]></category>
		<category><![CDATA[Rab10 phosphorylation]]></category>
		<category><![CDATA[siRNA screen]]></category>
		<category><![CDATA[VPS35 D620N]]></category>
		<category><![CDATA[whole-exome sequencing]]></category>
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					<description><![CDATA[A new study finds that about fourteen percent of Parkinson's patients without recognised pathogenic mutations show LRRK2 pathway activation as strong as that seen in carriers of known genetic causes, pointing to hidden genetic modifiers and reshaping patient stratification for LRRK2-targeted therapies.]]></description>
		
		
		
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