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	<title>myeloproliferative neoplasms &#8211; BIOENGINEER.ORG</title>
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		<title>Calreticulin Is Not the MHC Class I Gatekeeper Immunology Textbooks Claimed</title>
		<link>https://bioengineer.org/calreticulin-is-not-the-mhc-class-i-gatekeeper-immunology-textbooks-claimed/</link>
		
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		<pubDate>Sat, 17 Oct 2026 15:12:36 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[antigen presentation]]></category>
		<category><![CDATA[calreticulin]]></category>
		<category><![CDATA[cancer vaccination]]></category>
		<category><![CDATA[cells]]></category>
		<category><![CDATA[chaperone biology]]></category>
		<category><![CDATA[Haematopoietic]]></category>
		<category><![CDATA[Immunopeptidomics]]></category>
		<category><![CDATA[MHC class I]]></category>
		<category><![CDATA[myeloproliferative neoplasms]]></category>
		<category><![CDATA[oncogenic CALR mutations]]></category>
		<category><![CDATA[peptide loading complex]]></category>
		<category><![CDATA[T cell response]]></category>
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					<description><![CDATA[A new study finds that calreticulin, long considered an essential chaperone for MHC class I antigen presentation, is functionally expendable in that role, with oncogenic variants and calreticulin deficiency leaving T cell responses intact across cell lines, primary cells, mice, and patient samples.]]></description>
		
		
		
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