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		<title>Immune-cell switch flips the metabolic war between tumors and T cells in immunotherapy-resistant cancers</title>
		<link>https://bioengineer.org/immune-cell-switch-flips-the-metabolic-war-between-tumors-and-t-cells-in-immunotherapy-resistant-cancers/</link>
		
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		<pubDate>Wed, 14 Oct 2026 15:38:42 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[Cancer immunotherapy]]></category>
		<category><![CDATA[CAR-T cells]]></category>
		<category><![CDATA[CD8+ T cells]]></category>
		<category><![CDATA[checkpoint blockade]]></category>
		<category><![CDATA[chromatin remodeling]]></category>
		<category><![CDATA[Colorectal cancer]]></category>
		<category><![CDATA[CPT1A]]></category>
		<category><![CDATA[Fatty Acid Oxidation]]></category>
		<category><![CDATA[immune evasion]]></category>
		<category><![CDATA[metabolic competition]]></category>
		<category><![CDATA[PPARδ]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[A new study shows that activating the lipid sensor PPARδ in immune cells rather than cancer cells flips the metabolic competition inside tumors, empowering CD8 T cells to overcome immunotherapy resistance in colorectal cancer and boosting human CAR-T cell function.]]></description>
		
		
		
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