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	<title>MCH-02 &#8211; BIOENGINEER.ORG</title>
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		<title>Synthetic Macamide Analog Reshapes Hippocampal Endocannabinoid System but Fails to Prevent Seizure Progression in Rats</title>
		<link>https://bioengineer.org/synthetic-macamide-analog-reshapes-hippocampal-endocannabinoid-system-but-fails-to-prevent-seizure-progression-in-rats/</link>
		
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		<pubDate>Fri, 16 Oct 2026 20:03:31 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[analog]]></category>
		<category><![CDATA[BK channels]]></category>
		<category><![CDATA[Endocannabinoid System]]></category>
		<category><![CDATA[epilepsy]]></category>
		<category><![CDATA[FAAH inhibitor]]></category>
		<category><![CDATA[Hippocampus]]></category>
		<category><![CDATA[macamide]]></category>
		<category><![CDATA[MCH-02]]></category>
		<category><![CDATA[PTZ kindling]]></category>
		<category><![CDATA[seizure susceptibility]]></category>
		<category><![CDATA[synthetic]]></category>
		<category><![CDATA[vitro]]></category>
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					<description><![CDATA[A new FAAH-inhibiting macamide analog, MCH-02, induced significant molecular remodeling of the hippocampal endocannabinoid system and BK channel expression in a rat epilepsy model, yet it did not prevent PTZ-induced progressive seizure susceptibility and transiently worsened seizure severity.]]></description>
		
		
		
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