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	<title>loss-of-function &#8211; BIOENGINEER.ORG</title>
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		<title>CRISPR frame-restoring edit revives lost tomato gene and boosts fruit nutrition</title>
		<link>https://bioengineer.org/crispr-frame-restoring-edit-revives-lost-tomato-gene-and-boosts-fruit-nutrition/</link>
		
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		<pubDate>Thu, 15 Oct 2026 09:54:09 +0000</pubDate>
				<category><![CDATA[Agriculture]]></category>
		<category><![CDATA[chlorophyll]]></category>
		<category><![CDATA[CRISPR-Cas12a]]></category>
		<category><![CDATA[domestication trade-offs]]></category>
		<category><![CDATA[Genome editing]]></category>
		<category><![CDATA[loss-of-function]]></category>
		<category><![CDATA[Plant Cell Reports]]></category>
		<category><![CDATA[plastid development]]></category>
		<category><![CDATA[Reactivation]]></category>
		<category><![CDATA[SlGLK2]]></category>
		<category><![CDATA[tocopherol]]></category>
		<category><![CDATA[tomato]]></category>
		<category><![CDATA[uniform ripening]]></category>
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					<description><![CDATA[Researchers used a temperature-tolerant LbCas12a genome editing system to restore the reading frame of a loss-of-function SlGLK2 allele in tomato, recovering the green shoulder phenotype and increasing soluble solids and tocopherol content in ripe fruit.]]></description>
		
		
		
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