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	<title>leptomeningeal disease &#8211; BIOENGINEER.ORG</title>
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		<title>When Breast Cancer Spreads Only to the Brain, a Distinct Disease Emerges</title>
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		<pubDate>Wed, 07 Oct 2026 12:51:17 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[brain metastases]]></category>
		<category><![CDATA[brain-only metastatic breast cancer]]></category>
		<category><![CDATA[Breast Cancer]]></category>
		<category><![CDATA[CNS-penetrant therapies]]></category>
		<category><![CDATA[intracranial progression]]></category>
		<category><![CDATA[leptomeningeal disease]]></category>
		<category><![CDATA[National Cancer Database]]></category>
		<category><![CDATA[radiation oncology]]></category>
		<category><![CDATA[stereotactic radiosurgery]]></category>
		<category><![CDATA[Systemic therapy]]></category>
		<category><![CDATA[triple-negative breast cancer]]></category>
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					<description><![CDATA[A large national registry analysis and an institutional cohort suggest that breast cancer metastasizing exclusively to the brain constitutes a distinct clinical entity with unique biology, treatment patterns, and survival outcomes.]]></description>
		
		
		
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