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	<title>KLHDC3 E3 ligase &#8211; BIOENGINEER.ORG</title>
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	<title>KLHDC3 E3 ligase &#8211; BIOENGINEER.ORG</title>
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		<title>Monovalent Pseudo-Natural Products Boost IDO1 Degradation</title>
		<link>https://bioengineer.org/monovalent-pseudo-natural-products-boost-ido1-degradation/</link>
		
		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Wed, 07 Jan 2026 16:46:36 +0000</pubDate>
				<category><![CDATA[Chemistry]]></category>
		<category><![CDATA[Immunotherapy** * **IDO1 degradation:** Makalenin temel konusu ve hedefi. * **Monovalent pseudo-natural products:** Keşfedilen yeni molekül sınıfı ve ana]]></category>
		<category><![CDATA[KLHDC3 E3 ligase]]></category>
		<category><![CDATA[Makale içeriğine ve anahtar kavramlara göre en uygun 5 etiket: **IDO1 degradation]]></category>
		<category><![CDATA[Monovalent pseudo-natural products]]></category>
		<category><![CDATA[targeted protein degradation]]></category>
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					<description><![CDATA[In a breakthrough that promises to redefine the landscape of targeted protein degradation, researchers have unveiled a novel class of monovalent pseudo-natural products capable of dramatically enhancing the degradation of the immunosuppressive enzyme IDO1 through its native E3 ligase, KLHDC3. This pioneering work, recently published in Nature Chemistry, offers a fresh molecular strategy that exploits [&#8230;]]]></description>
		
		
		
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