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	<title>iron dysregulation &#8211; BIOENGINEER.ORG</title>
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		<title>Microglial iron transport failure drives dopaminergic neuron loss in Parkinson&#8217;s models</title>
		<link>https://bioengineer.org/microglial-iron-transport-failure-drives-dopaminergic-neuron-loss-in-parkinsons-models/</link>
		
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		<pubDate>Mon, 26 Oct 2026 19:42:38 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[dopaminergic neurons]]></category>
		<category><![CDATA[ferroptosis]]></category>
		<category><![CDATA[iron dysregulation]]></category>
		<category><![CDATA[LCN2]]></category>
		<category><![CDATA[microglia]]></category>
		<category><![CDATA[neurodegeneration]]></category>
		<category><![CDATA[NgBR]]></category>
		<category><![CDATA[NUS1]]></category>
		<category><![CDATA[Parkinson’s disease]]></category>
		<category><![CDATA[PERK–ATF4–NUPR1 signaling]]></category>
		<category><![CDATA[SLC22A17]]></category>
		<category><![CDATA[substantia nigra]]></category>
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					<description><![CDATA[A Nature Neuroscience study in mouse and cell models reports that losing the Parkinson's risk protein NgBR in microglia triggers an LCN2–SLC22A17 iron-transport axis that overloads dopaminergic neurons with iron and drives ferroptosis, and that blocking this axis or ferroptosis eased neuron loss and motor symptoms in the models.]]></description>
		
		
		
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