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		<title>Hidden Fibroblast Subtype Drives Lung Cancer Growth and Weakens Immunotherapy</title>
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				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[Cancer-associated fibroblasts]]></category>
		<category><![CDATA[CD8+ T cell exhaustion]]></category>
		<category><![CDATA[COL16A1]]></category>
		<category><![CDATA[EGFR-mutant NSCLC]]></category>
		<category><![CDATA[integrin beta 1]]></category>
		<category><![CDATA[lung adenocarcinoma]]></category>
		<category><![CDATA[Osimertinib]]></category>
		<category><![CDATA[pembrolizumab)]]></category>
		<category><![CDATA[single-cell RNA sequencing]]></category>
		<category><![CDATA[SMAD3]]></category>
		<category><![CDATA[Spatial transcriptomics]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[A multimodal single-cell and spatial study has uncovered a collagen-producing fibroblast subtype enriched in EGFR-mutant non-small cell lung cancer that fuels tumor growth and T-cell exhaustion, pointing to a new combination therapy strategy.]]></description>
		
		
		
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