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	<title>inosine &#8211; BIOENGINEER.ORG</title>
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	<title>inosine &#8211; BIOENGINEER.ORG</title>
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		<title>KRAS-mutant tumors flood themselves with adenosine to blind immune cells</title>
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		<pubDate>Tue, 13 Oct 2026 19:22:58 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[A2AR]]></category>
		<category><![CDATA[ADA]]></category>
		<category><![CDATA[adenosine]]></category>
		<category><![CDATA[cancer metabolism]]></category>
		<category><![CDATA[immune evasion]]></category>
		<category><![CDATA[Immunotherapy resistance]]></category>
		<category><![CDATA[inosine]]></category>
		<category><![CDATA[KRAS]]></category>
		<category><![CDATA[NT5E]]></category>
		<category><![CDATA[PD-1 blockade]]></category>
		<category><![CDATA[T Cells]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that can be reversed with ADA nanoparticles, NT5E silencing, or A2AR blockade to restore immunotherapy sensitivity.]]></description>
		
		
		
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