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	<title>inherited mutations &#8211; BIOENGINEER.ORG</title>
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		<title>Rare EGFR variant linked to sharply elevated lung cancer risk</title>
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		<pubDate>Mon, 26 Oct 2026 22:13:37 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[cancer genetics]]></category>
		<category><![CDATA[EGFR T790M]]></category>
		<category><![CDATA[genetic]]></category>
		<category><![CDATA[germline variation]]></category>
		<category><![CDATA[inherited]]></category>
		<category><![CDATA[inherited mutations]]></category>
		<category><![CDATA[lung adenocarcinoma]]></category>
		<category><![CDATA[lung cancer]]></category>
		<category><![CDATA[mutation]]></category>
		<category><![CDATA[never-smokers]]></category>
		<category><![CDATA[rare]]></category>
		<category><![CDATA[Southern Appalachia]]></category>
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					<description><![CDATA[A study of 3.37 million people of European ancestry associated the rare inherited EGFR T790M variant with about 25 times the overall lung cancer risk and 62 times the risk among never-smokers.]]></description>
		
		
		
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