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	<title>IL-23 &#8211; BIOENGINEER.ORG</title>
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		<title>Crohn&#8217;s Disease May Be Driven by a Self-Reinforcing Loop Between Gut Barrier, Immunity and Microbes</title>
		<link>https://bioengineer.org/crohns-disease-may-be-driven-by-a-self-reinforcing-loop-between-gut-barrier-immunity-and-microbes/</link>
		
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		<pubDate>Thu, 08 Oct 2026 06:00:26 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[AIEC]]></category>
		<category><![CDATA[Crohn's disease]]></category>
		<category><![CDATA[dysbiosis]]></category>
		<category><![CDATA[gut microbiota]]></category>
		<category><![CDATA[IL-23]]></category>
		<category><![CDATA[intestinal epithelial barrier]]></category>
		<category><![CDATA[JAK inhibitors]]></category>
		<category><![CDATA[Precision Medicine]]></category>
		<category><![CDATA[risankizumab]]></category>
		<category><![CDATA[short-chain fatty acids]]></category>
		<category><![CDATA[Th17 cells]]></category>
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					<description><![CDATA[A new review proposes that Crohn's disease is sustained by self-reinforcing feedback loops linking epithelial barrier failure, immune hyperactivation and microbial dysbiosis, and argues that multi-target, mechanism-guided therapies could break the cycle.]]></description>
		
		
		
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